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	Provedor de dados BJMBR (3) Autor Baxmann,A.C. (1) Bazotte,R.B. (1) Curi,R. (1) Goldstein,J. (1) Heilberg,I.P. (1) Ibarra,C. (1) Nascimento,K.F. (1) Nishiura,J.L. (1) Pagliarini e Silva,S. (1) Silberstein,C. (1) Vardanega-Peicher,M. (1) Vendramini,L.C. (1) Mais... Palavra-chave Cyclic AMP (3) ADPKD (1) Adenylyl cyclase (1) COS-7 cells (1) Caffeine (1) Glycogen breakdown (1) Insulin-induced hypoglycemia (1) Liver metabolism (1) Nitric oxide (1) Nutrition (1) Polycystic kidneys (1) Renal volume (1) Signal transduction (1) Sodium nitroprusside (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2012 (1) 2003 (1) 2002 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide BJMBR Goldstein,J.; Silberstein,C.; Ibarra,C.. Adenylyl cyclase (AC) isoforms catalyze the synthesis of 3',5'-cyclic AMP from ATP. These isoforms are critically involved in the regulation of gene transcription, metabolism, and ion channel activity among others. Nitric oxide (NO) is a gaseous product whose synthesis from L-arginine is catalyzed by the enzyme NO synthase. It has been well established that NO activates the enzyme guanylyl cyclase, but little has been reported on the effects of NO on other important second messengers, such as AC. In the present study, the effects of sodium nitroprusside (SNP), a nitric oxide-releasing compound, on COS-7 cells transfected with plasmids containing AC types I, II, V and VI were evaluated. Total inhibition (~98.5%) of cAMP production was observed in COS-7... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adenylyl cyclase; Nitric oxide; Sodium nitroprusside; Cyclic AMP; COS-7 cells; Signal transduction. Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000200002 Caffeine intake by patients with autosomal dominant polycystic kidney disease BJMBR Vendramini,L.C.; Nishiura,J.L.; Baxmann,A.C.; Heilberg,I.P.. Because caffeine may induce cyst and kidney enlargement in autosomal dominant polycystic kidney disease (ADPKD), we evaluated caffeine intake and renal volume using renal ultrasound in ADPKD patients. Caffeine intake was estimated by the average of 24-h dietary recalls obtained on 3 nonconsecutive days in 102 ADPKD patients (68 females, 34 males; 39 ± 12 years) and compared to that of 102 healthy volunteers (74 females, 28 males; 38 ± 14 years). The awareness of the need for caffeine restriction was assessed. Clinical and laboratory data were obtained from the medical records of the patients. Mean caffeine intake was significantly lower in ADPKD patients versus controls (86 vs 134 mg/day), and 63% of the ADPKD patients had been previously aware of caffeine... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polycystic kidneys; ADPKD; Cyclic AMP; Caffeine; Nutrition; Renal volume. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900007 Responsiveness of glycogen breakdown to cyclic AMP in perfused liver from rats with insulin-induced hypoglycemia BJMBR Vardanega-Peicher,M.; Curi,R.; Pagliarini e Silva,S.; Nascimento,K.F.; Bazotte,R.B.. The responsiveness of glycogen breakdown to cAMP was investigated in isolated perfused liver from male Wistar fed rats (200-220 g) with insulin-induced hypoglycemia. The activation of glycogenolysis by 3 µM cAMP was decreased (P<0.05) in livers from rats with hypoglycemia induced by the administration of insulin or during the direct infusion of insulin into the isolated liver. The direct effect of insulin on glycogen catabolism promoted by 3 µM cAMP occurred as early as 3 min after starting insulin infusion. In contrast, the cAMP agonists resistant to phosphodiesterases, 8Br-cAMP and 6MB-cAMP, used at the same concentration as cAMP, i.e., 3 µM, did not modify the effect of insulin. The data suggest that the decreased hepatic responsiveness of glycogen... Tipo: Info:eu-repo/semantics/article Palavras-chave: Insulin-induced hypoglycemia; Cyclic AMP; Glycogen breakdown; Liver metabolism. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000100007 Registros recuperados: 3 Primeira ... 1 ... Última

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